The Cell Based Model of in-vivo Coagulation: A Work in Progress

The goal of this article is to review the evolution of theories of coagulation and their proposed models to serve as a tool. When reviewing the research and practice literature that was published in the context of these theories over time, including the critical contribution of cells, we have observed a model based on work of many workers, in which Hemostasis is regulated by various properties of cell surface, which occurs in vivo. The coagulation occurs not as a cascade/waterfall, but occurs in 4 overlapping steps-(i) Initiation, (ii) Amplification, (iii) Propagation, (iv) Termination. Cell Based model has given an insight into the pathophysiological mechanism of certain coagulation disorders which were till now ill understood.