Synthesis of Pharmacologically Important Some Novel Pyrimidine and Chalcone Moieties Containing s-triazines

s-Triazines containing heterocycles have variety of biological activities including anti-cancer, anti-viral, anti-microbial, anti-inflammatory activities. Various heterocycles have been synthesized by annellation methodology using chalcones as base template. A new series of 2-aminopyrimidine substituted chalcones have been synthesized by the temperature controlled reaction of s-triazines. 4,6-Dichloro-N-(pyrimidine-2-yl)-1,3,5-triazine-2-amine and its various derivatives were synthesized at different temperatures. These were further treated with pyridine-2-aldehydes to furnish corresponding chalcones and the newly synthesized compounds were characterized by IR, 1H-NMR, MS and elemental analysis. s-Traizine containing chalcones have been used as base framework to synthesized five-, six- and seven-membered heterocycles through annellation methodology.