Synthesis and Evaluation of Antibacterial Properties of Chalcones Derived from Thiophene-2-Carbaldehyde

Chalcone is a simple chemical structure which is present in most of the naturally occurring substances. Many chalcone derivatives are synthesized by Claisen-Schmidt condensation reaction. It is a subject of great research opportunity due to numerous biological activities and convenient synthesis of chalcones. This study aims on synthesizing different α, β unsaturated ketones (chalcones) containing thiophene from thiophene-2-carbaxldehyde and different substituted acetophenones, further evaluating antibacterial activity of synthesized compounds. The synthesized compounds are characterized for their spectral study. From the antibacterial study it was observed that the compounds bearing electron withdrawing group, electron releasing group exhibited excellent to moderate antibacterial activity respectively. These results showed that chalcones incorporated with thiophene have better scopes for further development of the antimicrobial agents.