Localized Laryngeal Amylodosis Successful Treatment with Systemic Therapy — A Case Report

Amyloidosis is a rare idiopathic extracellular deposition of an amorphous amyloid substance in tissues which ultimately leads to organ malfunction and failure. Clinically, amyloidosis is divided into 2 categories; systemic and localized. Localized amyloidosis is rare and clinical presentation is variable and often non-specific ranging from simple hoarseness, dysphagia and bleeding to lethal airway obstruction, depending on size and location of the amyloid deposition.

The main treatment for laryngeal amyloidosis is by surgical intervention, however medical treatment is an option in certain case. We reported a case of patient presented with hoarseness and been diagnosed as laryngeal amyloidosis. As the patient refused for surgical intervention, he was treated with oral thalidomide. After five years of close follow-up, patient shows improvement with no evidence of disease progression or airway compromise.