Rare Association of an Aggressive Giant Cell Tumor with Xeroderma Pigmentosum

Xeroderma pigmentosum (XP) is a genodermatosis that manifests as photo-induced skin and ocular alterations and skin cancers. An association with a giant cell tumor is a very rare entity. We report the case of a 17-year-old patient, followed since childhood for XP, who presented with a very aggressive giant cell tumor in the wrist for which he underwent amputation. A review of the literature of these rare lesions is presented and analyzed to see if this is an association or is a chance coincidence.