Correlation of Leptin and Vaspin Serum Concentration in Newly Diagnosed Type 2 Diabetes Mellitus

Objectives: The aim of the study was to explore the correlation of circulating leptin and vaspin levels with lipid profile, fasting blood sugar, HbA1c and anthropometric variable as inflammatory markers between diabetic patients and non-diabetic subjects.

Material and Methods: This study was conducted with 120 newly diagnosed type 2 diabetes mellitus (T2DM) patients with age-matched 120 non-diabetic subjects as controls.

Results: We found that there is significant increase in the parameters like serum Leptin, Vaspin, FBS, PPBS, HbA1c and lipid profile (TC, TG & VLDL). No significant differences were found between BMI, LDL & HDL parameters of T2DM patients compared to non-diabetic subjects. The results have been shown a significant positive correlation between Vaspin and Leptin in T2DM patients, (r = .755) and (P˂0.01) as compared to controls. The body mass index was positively correlated with Vaspin in T2DM patients, (r = .50) and (P <0.01) and with leptin in T2DM patients, (r = .265) and (P <0.01). A positive correlation had also observed between vaspin and LDL in T2DM patients, (r = .189) and (p <0.05). We also found that significant increased level of leptin and vaspin in females compared to males in our study group.

Conclusions: Serum leptin and vaspin level is positively associated with BMI and LDL and negatively correlated with fasting blood sugar, post-prandial glucose, HbA1c, VLDL and age.